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Journal 'Cytokines & inflammation', 2004, No. 2

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Number 2'2004

THE ROLE OF CYTOKINES IN ACUTE SURGICAL ABDOMINAL PATHOLOGY

S.V. Minaev

The study of cytokines in the sera of 34 phlegmonous appendicitis patients showed an increase of proinflammatory cytokine levels: IL-2 up to 466,5 + 46,9 pg/ml (p " 0,01), TNFa up to 101,1 + 17,5 pg/ml (p " 0,05), IL-6 - 102,9 + 12,1 pg/ml, and increase of anti-inflammatory cytokine IL-4 up to 27,3 + 4,1 pg/ml (p " 0,05). Administration of polyenzyme medication Wobenzym after surgical treatment led to normalization of cytokine levels due to proinflammatory cytokine (IL-2, IL-6, TNFa) decrease and increase of anti-inflammatory cytokine (IL-4). This allowed to prevent complications in patients who underwent an appendectomy. (Cytokines and Inflammation. 2004. Vol. 3, ь 2. P. 41-46.)

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