197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
E-mail:
Web: cytokines.ru

  

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2004, No. 3

IMMUNOMODULATOR POLYOXIDONIUM: MECHANISMS OF ACTION AND ASPECTS OF CLINICAL APPLICATION

B.V. Pinegin, A.V. Nekrasov, R.M. Khaitov

Original and literature data regarding mechanisms of action and clinical use of a new Russian immunomodulator Polyoxidonium, which is a high-molecular weight compound with prominent immunotropic activity, are reviewed in the article. Polyoxidonium has an impact upon every step of immune defence by normalizing immune functions; therefore, Polyoxidonium is true immunomodulator. Phagocytic cells and natural killers are target cells for Polyoxidonium. It can stimulate or co-stimulate IL-1b, IL-6, TNFa and a-interferon production by these cells. Polyoxidonium increases phagocytes' ability to kill bacteria. In case of humoral immunodeficiency, Polyoxidonium significantly stimulates antibody production. Besides the immunomodulating ability, Polyoxidonium demonstrates detoxicative, antioxidant and membrane stabilizing activity. Due to these facts, Polyoxidonium became irreplaceable component in complex treatment of acute and chronic infections and in oncology patients' immune rehabilitation. Mode of application of Polyoxidonium together with etiotropic drugs in secondary immunodeficiency conditions, which significantly increases treatment effectiveness, is founded in the article. (Cytokines and Inflammation. 2004. Vol. 3, No. 3. P. 41-47.)

Keywords: Polyoxidonium, leukocytes, immune response, immunodeficiencies.

Contents | Next article | Previous article