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Journal 'Cytokines & inflammation', 2004, No. 3

MECHANISMS OF INFLAMMATORY REACTION AND PROTEOLYTIC ENZYMES INFLUENCE UPON THEM

M. Lysikova, M. Wald, Z. Masinovsky

Inflammation belongs to the oldest defence mechanisms. Although a wide range of stimuli may trigger the cascade of an inflammatory reaction, there are always five systems interacting in the body defense: endothelial cells, platelets, leucocytes, coagulation system and complement system. However, these systems have also a strong autoaggressive potential which can lead to the situation when the inflammatory process crosses the barrier of an effective protective tool and the tissue becomes altered by a chronic inflammation or even by an autoimmune disease onset. The aim of this article is to demonstrate how the systemically administered proteases of animal and plant origin, widely used in the treatment of inflammatory conditions, can successfully optimize the interaction between the above mentioned systems. Direct proteolysis and the cytokine binding affinity of a2-macroglobulin-protease complex are considered. (Cytokines and Inflammation. 2004. Vol. 3, No. 3. P. 48-53.)

Keywords: inflammation, a2-macroglobulin, cytokines, peroral enzymes, proteases.

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