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Journal 'Cytokines & inflammation', 2005, No. 3

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Reviews

Number 3'2005

TNFA FUNCTIONAL GENE POLYMORPHISM AND PATHOLOGY

A.V. Rydlovskaya, A.S. Simbirtsev

This review article is devoted to two (most significant for human) nucleotide substitutions in promoter region of TNFA gene. These substitutions' influence on TNFa production level and their contribution to development and outcome of diseases of various etiologies are discussed. (Cytokines and Inflammation. 2005. Vol. 4, № 3. P. 4-10.)

Keywords: gene polymorphism, cytokines, TNFa, inflammation, predisposition to human pathology.

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