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Journal 'Cytokines & inflammation', 2005, No. 3

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Original Articles

Number 3'2005

THE IMPACT OF CYTOKINES ON AUTOIMMUNE B-CELL DESTRUCTION IN HBV AND HCV-INFECTED PATIENTS WITH TYPE II DIABETES MELLITUS

L.Yu. Khamnueva, I.V. Malov, L.Yu. Andreeva, O.V. Shagun, V.P. Zudaev

The aim of the investigation was to study frequency of anti-pancreatic islet cells (ICA) and anti-glutamic acid decarboxylase (GADA) antibodies in comparison with cytokines serum levels in order to elucidate cytokines' pathogenic importance in autoimmune destruction of b-cells in HBV- and HCV-infected patients with type II diabetes mellitus (DM II). GADA were revealed in 39,6 % (28 from 111) of HBV-infected patients, ICA in 25 % (28 from 111) of HCV-infected patients compared to 9,7 % (6 from 62) and 1,6 % (1 from 62) in non-infected DM II patients. In non-infected patients, ICA and GADA were not revealed simultaneously. Both kinds of antibodies were revealed in 15 (13,5 %) HBV- and HCV-infected patients. The frequency of ICA and GADA did not depend on the virus replication phase. Thus, HBV- and HCV- infection may be an initiating factor for the autoimmune aggression directed to b-cells development. High serum levels of IL-1b (100,38 pg/ml) and IL-4 (36,85 pg/ml) were detected in GADA- and ICA-positive DM II patients infected with HBV and HCV compared to lower levels of these cytokines in the GADA- and ICA-negative group (35,0 pg/ml and 13,72 pg/ml, respectively) (p = 0,021, p = 0,04). Statistically insignificant differences were found in the serum contents of TNFa, IL-6 and IFNa. Thus, we have established the considerable role of IL-1b, IL-4 cytokines in b-cells destruction in DM II patients infected with HBV and HCV. (Cytokines and Inflammation. 2005. Vol. 4, № 3. P. 20-24.)

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