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Journal 'Cytokines & inflammation', 2005, No. 3

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Original Articles

Number 3'2005

FEATURES OF IFNG SYSTEM IN PATIENT WITH HIGH RATE OF HERPES SIMPLEX RECURRENCE. A CASE REPORT

L.V. Pichugina, A.D. Chernousov, B.V. Pinegin

In a group of patients with high rate of recurrent herpes simplex of different location, a patient was found with resistance to standard treatment. When investigating his IFNg system, the following peculiarities were observed. The production of IFNg by peripheral blood cultures as well as the blood cell expression of IFNg receptor alpha chain were normal. However the patient's peripheral blood cells showed low response to IFNg stimulation in vitro measured by IL-12 (IL-12p70) production. It is suggested that this dysfunction may be a result of IFNg receptor signal pathway disruption induced by HSV. It may be a cause of both chronic course of the infection and drug resistance development. (Cytokines and Inflammation. 2005. Vol. 4, № 3. P. 28-30.)

Keywords: herpes, interferon gamma, interferon receptor, IL-12.

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