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Journal 'Cytokines & inflammation', 2006, No. 1

NITRIC OXIDE LEVEL INCREASING AND HYPERFIBRINOGENEMIA IN THE PATHOGENESIS OF COMBINED RADIATION-THERMAL INJURIES

R.S. Budagov, L.P. Ulianova, S.Ya. Proskuryakov

The influence of S-ethyl-isothiourea, a specific inhibitor of inducible NO* synthase (as "Difetur" preparation) on hepatic NO* production level, blood fibrinogen level, and 30-days survival of (CBA x C57BL/6)F1 mice under combined radiation/thermal injury (CRTI; whole body g-irradiation at the dose of 7 Gy + 10 % body surface full-thickness thermal burn) was evaluated. Pretreatment of mice with Difetur led to complete inhibition of NO* production. Animals received Difetur during the first 2 days after CRTI showed a 2-fold decrease of fibrinogen levels in 9 days after CRTI and 60 % survival vs 15 % in "CRTI-control" group. It was suggested that the growth of NO* production in the early period of CRTI increases sensitivity of animals to endotoxin and infection leading to death on 10-12 day. (Cytokines and Inflammation. 2006. Vol. 5, N 1. P. 53-55.)

Keywords: combined radiation-thermal injuries, nitric oxide, fibrinogen, survival, nitric oxide synthase inhibitor.

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