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Journal 'Cytokines & inflammation', 2006, No. 1

CYTOKINE PRODUCTION BY DECIDUAL MACROPHAGES IN UNCOMPLICATED PREGNANCY AND INTRAUTERINE GROWTH RETARDATION

N.Yu. Sotnikova, A.V. Kudryashova, N.V. Kroshkina, I.A. Panova, M.V. Vedeneeva, Yu.V. Gagaeva, V.N. Gorodkov

Flow cytometry evaluation of cytokine intracellular expression showed the decrease of intracellular IL-1b, IL-10, IL-12 synthesis by decidual macrophages in intrauterine growth retardation (IUGR) pregnancy. IUGR was accompanied by significant decrease of IL-1b, IL-10 levels and increase of IL-12 concentration in extracts of decidual tissue. Decidual macrophages in IUGR pregnancy were characterized by diminished MHC antigens expression and elevation of CD11b+ pool of cells. Thus, inadequate activation of decidual macrophages associated with impairment of cytokine synthesis and antigen presenting function, was seen in IUGR pregnancy. (Cytokines and Inflammation. 2006. Vol. 5, N 1. P. 16-20.)

Keywords: intrauterine growth retardation, cytokines, decidual macrophages.

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