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Journal 'Cytokines & inflammation', 2006, No. 2

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Reviews

Number 2'2006

IMMUNE SYSTEM DYSFUNCTION IN SEPSIS: DIAGNOSTIC POSSIBILITIES

V.K. Kozlov

State University named after Yaroslav The Wise, Velikiy Novgorod

Immune dysfunctions in generalized forms of hospital infections, including severe sepsis and septic shock, are reviewed. The necessity of recognizing the immune system dysfunction as a part of multiple organ failure pathogenesis is substantiated . The roles of antigenemia, components of systemic immune response, immunosuppression, phenotypic (lymphocyte subpopulations) and regulatory (cytokine profile) imbalance, and anergy of lymphocytes, monocytes/macrophages and granulocyte phagocytes are discussed. The necessity of immune insufficiency revealing is suggested. Diagnostic criteria for general immunosuppression as a sign of multiple organ failure are reviewed. (Cytokines and Inflammation. 2006. Vol. 5, № 2. P. 15-29.)

Keywords: sepsis, septic chock, systemic inflammatory response, immunosuppression, multiple organ failure, immune factors, pathogenesis.

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