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Journal 'Cytokines & inflammation', 2006, No. 2

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Original Articles

Number 2'2006

BESTIM IN CORRECTION OF NEUTROPHIL GRANULOCYTES DYSFUNCTION IN PATIENTS WITH COMPLICATED CHRONIC PANCREATITIS BY IN VITRO EXPERIMENT

I.V. Nesterova, I.N. Shvydchenko, I.V. Fesenko

The aim of the work was to study functional disorders in the system of neutrophil granulocytes (NG) in patients with complicated chronic pancreatitis (CCP), with determination of the possibility of their correction in vitro with dipeptide Bestim (g-D-glutamyl-L-tryptophan). Depressed NG phagocytic activity, reduced oxygen-dependent microbicidal potential and significantly changed NG membrane receptors expression were observed in CCP patients. Bestim displayed strong immunomodulating activity in vitro for NG of patients with CCP. The peptide acts to normalize NG dysfunctions by stimulating of NG membrane receptors expression. (Cytokines and Inflammation. 2006. Vol. 5, № 2. P. 42-46.)

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