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Journal 'Cytokines & inflammation', 2006, No. 4

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Original Articles

Number 4'2006

C-REACTIVE PROTEIN: A FACTOR OF INFLAMMATION BINDING AND INACTIVATING ACETYLCHOLINE

P.G. Nazarov, I.B. Krylova, N.R. Evdokimova, G.I. Nezhinskaya, A.A. Butyugov

C-reactive protein (CRP), a marker of inflammation and factor of innate immunity, binds phosphorylcholine (PC) and PC-containing compounds. Based on structural similarity between PC and acetylcholine (ACh) we investigated the ability of purified human CRP to bind ACh and influence its physiological activity and susceptibility to breakdown with acetylcholinesterase (AChE). The results showed that CRP binds ACh. CRP significantly lowered the cardio-vascular response of rats to ACh infusion and protected ACh from hydrolysis by AChE in vitro. It is suggested that CRP effects on cardio-vascular system in vivo is mediated through ACh-dependent mechanisms. (Cytokines and Inflammation. 2006. Vol. 5, ь 4. P. 32-35.)

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