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Journal 'Cytokines & inflammation', 2007, No. 1
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Original Articles
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Number 1'2007
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THE ROLE OF CYTOKINES IN IMMUNOPATHOGENESIS OF UVEITIS ASSOCIATED WITH RHEUMATIC DISEASE
E.A. Drozdova1, S.N. Teplova2
1 Ural State Medical Academy for Additional Education, 2 Chelyabinsk State Medical Academy, Chelyabinsk
Purpose: To determine the systemic and topical levels of some proinflammatory and antiinflammatory cytokines in patients with uveitis associated with rheumatic diseases (RD). Methods: We investigated contents of TNFα, IFNγ, IL-4, soluble receptor I to TNFα (р55) in serum and tears and production of TNFα by monocytes of peripheral blood in 46 patients with acute uveitis and 30 healthy donors. Results: levels of TNFα, IFNγ in serum were 5 times greater than in control but concentrations of IL-4 and р55 were only 2 times higher in patients in comparison with healthy donors. Ratio of IFNγ to IL-4 in serum and tears was 2,6 times higher in patients with uveitis. We revealed increased spontaneous production of TNFα by blood monocytes that correlated with TNFα serum level and severity of uveitis. Contents of TNFα in tears from uveitis eye was increased 10 times in comparison with control and 30 times in comparison with its level in serum, but concentration of p55 was unchanged. Conclusion: Disturbance of the cytokine regulation of the immune homeostasis is a typical sign of uveitis associated with RD that is characterised by Th1 deviation of immune response. The main role in intraocular inflammation belongs to local production of proinflammatory cytokines. (Cytokines and Inflammation. 2007. Vol. 6, No. 1. P. 15-19 .)
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