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Journal 'Cytokines & inflammation', 2007, No. 3

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Original Articles

Number 3'2007

CYTOKINE BALANCE IN PATIENTS WITH PARKINSON AND WILSON - KONOVALOV DISEASES

O.N. Uchakina, P.N. Uchakin, M.V. Mezentseva, A.V. Karabanov, V.V. Poleschuk, I.A. Ivanova-Smolenskaya, F.I. Yershov

The problem of neurological diseases among elderly and middle-aged people becomes more and more significant and important with the constant increase of the lifespan and increasing stress related to advancing technology. Secondary immune deficiencies often correlate with different neurological and psychiatric diseases. The main purpose of this study was to investigate cytokine cascade in patients with Parkinson's and Wilson - Konovalov's diseases receiving regular treatment.

In both groups of patients, plasma levels of IFNγ, IL-1β, IL-2, IL-6, and IL-10 were significantly lower while concentrations of IL-4, IL-12, and TNFα higher compared to normal levels of healthy donors. Additionally, we observed significant differences in gene expression of Th1 (IFNγ and IL-12) and Th2 (IL-4, IL-6) cytokines as measured by RT-PCR technique. Blood cell's production of IFNα in vitro was dramatically suppressed in both groups of patients though gene expression of IFNα and its plasma level were near normal. The data suggests suppression of antiviral immunity at post-translation level. For this reason, the use of interferon-inducers for stimulation of endogenous interferon production would be more effective than the use of recombinant interferons for immuno-correction in neurological and psychiatric patients. (Cytokines and Inflammation. 2007. Vol. 6, No. 3. P. 63-68.)

Keywords: neurodegeneration, extrapyramidal disease, interleukins, interferon.

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