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Journal 'Cytokines & inflammation', 2008, No. 2

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Original Articles

Number 2'2008

A STUDY OF ANTI-INFLAMMATORY PROPERTIES OF GLYPROLINES USING EXPERIMENTAL MODEL OF THE ACUTE PERITONITIS IN RATS

Z.V. Bakaeva, G.E. Samonina, B.A. Umarova, G.N. Kopylova, E.L. Goncharova, K.E. Baglikova

Our previous experiments showed that glyprolines - Pro-Gly-Pro (PGP), Pro-Gly (PG) and Gly-Pro (GP) - reduced the formation and accelerated healing of gastric ulcers caused by application of ice acetic acid on the rat stomach mucosa. Considering that the formation of the acetic acid-induced gastric ulcers in rats includes strong inflammatory process, the purpose of the work was to investigate the anti-inflammatory properties of PGP, PG and GP peptides using experimental model of inflammation. Acute peritonitis caused in albino male rats by i. p. injection of 1 % acetic acid was accompanied by exudative reaction, migration of active blood cells in exudation, with prevalence of neutrophils. The biochemical analysis of blood revealed a change in parity of albuminous fractions characteristic of inflammation. Previous i. p. introduction of PGP, PG or GP in a dose of 3.7 ?mol/kg led to a decrease in neutrophil content in exudation in comparison with the control and to increase in eosinophil and plasmacyte contents. The levels of ?1- and ?2-globulins became near normal. The results suggest that РGP, PG and GP have an anti-inflammatory effect in experimental peritonitis that may be responsible for anti-ulcer effect of glyprolines. (Cytokines and Inflammation. 2008. Vol. 7, No. 2. P. 28-32.)

Keywords: glyprolines, peritonitis, exudation, blood proteins.

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