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Journal 'Cytokines & inflammation', 2008, No. 4

RECOMBINANT INTERLEUKIN 1β (BETALEUKIN) IN COMPLEX THERAPY OF NEONATAL SEPSIS

I.A. Zharov, V.G. Demikhov, A.V. Novikov, E.I. Dorofeeva, O.N. Zhurina, E.V. Demikhova,E.F. Morschakova, A.D. Pavlov, A.S. Simbirtsev

Efficiency of human recombinant interleukin 1β (Betaleukin) application in complex therapy of neonatal sepsis was studied. 38 newborn patients were included in the research. Betaleukin was administered by intravenous drop infusion, at doses of 2,5-5,0 ng/kg daily over 5 days. According to the obtained data, application of Betaleukin reduces severity of systemic inflammatory reaction, leads to fast restoration of normal hemostasis parameters, raises functional activity of leukocytes and decreases mortality in neonatal sepsis patients. (Cytokines and Inflammation. 2008. Vol. 7, ь 4. P. 63-66.)

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