Научно-практический журнал
[About us] Journal 'Cytokines & Inflammation'

197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
E-mail:
Web: cytokines.ru


  


Year 2013
Number 1 Number 2
Number 3

About journal

Archive

Columns
Subscription

Rules for authors

Contact us

Search

Site map

Our partners:

https://pornoseksxxx.com/

Русский языкEnglish language
Site map Contact us

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2009, No. 3

Subscribe for 2014 year

Order this issue

Order PDF of this article

Original Articles

Number 3'2009

Effect of pentoxyphylline on Th2 cytokine production in women with infertility associated with minimal endometriosis

Yu. S. Shaalali,Yu.S. Antsiferova, A.I. Malyshkina

The aim of the work was to investigate in vitro and in vivo the influence of pentoxyphylline upon Th2 cytokine production and estimate the possibility of using pentoxyphylline in infertility associated with minimal endometriosis treatment. The immunological investigation of 70 women with infertility and endometriosis before and after treatment with pentoxyphylline in early postoperative period was carried out. The enriched population of lymphocytes was incubated in RPMI 1640 medium in the presence of pentoxyphylline for 24 h in 37°С and 5 % СО2 to elucidate it’s immunomodulatory effect in vitro. Intracellular cytokines were detected with monoclonal antibodies by two-color flow cytometry. It was found that the level of IL-4+ and IL-6+ cells within the lymphocyte and T-helper populations and the number of IL-5+ lymphocytes were significantly increased in infertile women with minimal endometriosis. Incubation of lymphocytes with pentoxyphylline in vitro led to the decrease of IL-6 production by lymphocytes of healthy women and diminishment of IL-4 and IL-6 production by lymphocytes and CD4+ cells of infertile women with endometriosis. After course of treatment by pentoxyphylline, normalization of intracellular cytokines production was observed in women with endometriosis. Immunomodulatory effect of pentoxyphylline in vitro was associated with beneficial clinical effect of the drug upon reproductive function of infertile patients with endometriosis. (Cytokines and Inflammation. 2009. Vol. 8, № 3. P. 54-58.)

Contents | Next article | Previous article


© 2007-2014 Cytokines and inflammation


Warning: Unknown: Your script possibly relies on a session side-effect which existed until PHP 4.2.3. Please be advised that the session extension does not consider global variables as a source of data, unless register_globals is enabled. You can disable this functionality and this warning by setting session.bug_compat_42 or session.bug_compat_warn to off, respectively in Unknown on line 0