Научно-практический журнал
[About us] Journal 'Cytokines & Inflammation'

197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
Web: cytokines.ru


Year 2016
Number 1

About journal

Current year


Rules for authors

Contact us


Site map

Our partners:
Русский языкEnglish language ONAEGO
Site map Contact us

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2009, No. 4

Order this issue

Order PDF of this article

Original Articles

Number 4'2009

The distribution of genotypes of Helicobacter pylori, polymorphic loci of genes of cytokines (IL-1 and IL-10) and features of scarring of ulcerous defects in patients with duodenal ulcer

O.A. Chernova, E.R. Abuzarova, O.V. Gorshkov, N.B. Baranova, V.M. Chernov

The aim: An associative analysis of the distribution of H. pylori genotypes, polymorphic loci of genes of cytokines (IL-1 and IL-10) and morphometric parameters (size and scarring) of ulcerative defects in patients with duodenal ulcer in the city of Kazan. Methods: DNA samples obtained from 88 patients and 123 healthy individuals of the control group were used as research material. PCR and RFLP were used for genotyping of IL-1 and IL-10 in clinical samples. Results: It was found that the majority of patients with duodenal ulcer (inhabitants of Kazan) are carriers of highly virulent strains of H. pylori – cagA+vacAs1+. Allele IL-1B-511*C and the genotype IL-1B-511*C/*C increase the risk of duodenal ulcer associated with H. pylori, while the allele IL-1B-511*T and genotypes IL-1B-511*C/*T and IL-1RN*1/*2 reduces the probability of formation of the disease. Conclusions: Patients with IL-1RN*2/*2 genotype and/or infected with H. pylori cagA+vacAs1+ have a low probability for spontaneous cicatrisation of the ulcers. (Cytokines and Inflammation. 2009. Vol. 8, № 4. P. 28-31.)

Keywords: Helicobacter pylori, duodenal ulcer, cytokines, gene polymorphism.

Contents | Next article | Previous article

© 2007-2017 Cytokines and inflammation