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Journal 'Cytokines & inflammation', 2010, No. 3

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Original Articles

Number 3'2010

Endothelial dysfunction in pregnant women with preeclampsia depending on cytokine gene polymorphism

O.V. Radkov, M.N. Kalinkin, V.V. Zavarin

Peripheral microcirculation and endothelial function in women with preeclampsia depending on polymorphisms of (-308G/A) tumor necrosis factor-α gene (TNF) and (-1082 G/A) interleukin-10 gene (IL10) were studied. 45 women with normal pregnancy and 67 women with preeclampsia were evaluated. Peripheral microvascular responses were examined using the noninvasive technique of ultrasound Doppler flowmetry. The (-308G/A) TNF gene and (-1082 G/A) IL10 gene polymorphisms were detected with the use of the polymerase chain reaction. The allele A carrying of the (-1082 G/A) IL10 gene polymorphism was significantly increased in women who developed preeclampsia (p<0,05). The decreased endothelium-dependent vasodilatation in the microcirculation of preeclampsia women indicates abnormal endothelial function. Individuals with preeclampsia who are A allele carriers of the (-308G/A) TNF gene and (-1082 G/A) IL10 gene have most impaired endothelium-dependent vasodilatation (p<0,05). Thus peripheral microcirculation and endothelium function in pregnant women with preeclampsia depends on polymorphism of cytokine genes. (Cytokines and Inflammation. 2010. Vol. 9, № 3. P. 15-18.)

Key words: preeclampsia, endothelial dysfunction, gene polymorphism.

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