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Journal 'Cytokines & inflammation', 2011, No. 1

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Original Articles

Number 1'2011

Inflammatory mediators and humoral immune response to differentiation factor HLDF and cytokines in pulmonary tuberculosis patients with bronchial epithelium dysplasia

A.I. Autenshlyus, A.V. Sosnina, A.P. Lykov, Ye.S. Mikhailova, N.B. Kuznetsova, D.V. Morozov, Yu.V. Tumanov, Ye.D. Danilenko, V.V. Samukov, I.A. Kostanyan, N.A Varaksin

Interdependence between inflammatory mediators, humoral immune response to differentiation factor HLDF (Human Leukemia Differentiation Factor), cytokines and grade of bronchial epithelium dysplasia was studied in pulmonary tuberculosis patients. Serum levels of TNFα, IL-1β, IL-1Ra, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, IL-18, IFNα, IFNγ, IL-18BP and antibodies: IgG, IgM, IgA to HLDF, IgG, IgM, IgA and IgG1 IgG2, IgG3, IgG4 to TNFα, IgG and IgG1 IgG2, IgG3, IgG4 to IFNα, IgG and IgM to IFNγ were determined. Antibodies to HLDF were present in healthy individuals and in pulmonary tuberculosis patients, but high levels of IgG to HLDF were found only in the grade II–III of bronchial epithelium dysplasia, what was confirmed by positive correlation between those parameters. In grade II–III of bronchial epithelium dysplasia, high levels of IL-1β and IL-18BP were determined. The positive correlation between the levels of IL-1β and the grade of bronchial epithelium dysplasia were found. Appearance of bronchial epithelium cellular atypia in pulmonary tuberculosis may be connected with autoantibodies to HLDF which in the first place block inhibitory influence of this factor on binding of IL-1β with its receptors on bronchial epithelial cells leading to intensive proliferation of immature cells taking part in epithelium regeneration in chronic inflammation site, and in the second place block the differentiation effect of HLDF resulting in arise of atypical cells. (Cytokines and Inflammation. 2011. Vol. 10. № 1. P. 13–17.)

Keywords: cytokines, antibodies, HLDF, pulmonary tuberculosis.

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