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Journal 'Cytokines & inflammation', 2011, No. 3

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Number 3'2011

Interleukin 33 is a key mediator of immune response

V.V. Kolobov

Interleukin 33 (IL-33) is a member of IL-1 family. It can operate as non-histone DNA-binding protein that stabilizes nucleosome formation (intracellular function). IL-33 also stimulates mainly the production of pro-inflammatory cytokines by different cells of the body (extracellular function). IL-33 is a key mediator in immune response realization as it’s capable of activating antigen-presenting cells and T lymphocytes. In the process of immune inflammation this cytokine can also activate basophils, eosinophils, mast cells and invariant NK T cells. Up-to-date facts evidence that IL-33 primary assists in release of pro-inflammatory cytokines by Th2 lymphocytes (IL-5, IL-9, IL-13). (Cytokines and Inflammation. 2011. Vol. 10. № 3. P. 5–9)

Keywords: interleukin 33, immune response, pro-inflammatory cytokines.

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