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Journal 'Cytokines & inflammation', 2012, No. 1

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Number 1'2012

Immunomodulating properties of higher basidiomycetes mushrooms

M.M. Shamtsyan, E.V. Vorobeychikov, V.G. Konusova, A.S. Simbirtsev

There are about 700 mushrooms currently known to exhibit certain kinds of biological activity. Of the most interest to researchers is immunostimulatory activity of beta-D-glucans, which are components of mushroom cell wall. The mechanism of action of these polysaccharides is realized through their interac­tion with specific receptors on cells of innate immunity. Stimulation of the immune response determines the therapeutic effects produced by beta-D-glucans: anti-cancer, anti-infectious and anti-allergenic action. (Cytokines and Inflammation. 2012. Vol. 11. № 1. P. 26–32.)

Keywords: higher mushrooms, beta-D-glucans, innate immunity, receptors.

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