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Journal 'Cytokines & inflammation', 2012, No. 2

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Number 2'2012

The role of SOCS proteins in the negative regulation of JAK-STAT signaling

V.N. Mineev, L.N. Sorokina, V.V. Lim, M.A. Nyoma, V.A. Ivanov, G.I. Lipkin

In this review, we summarize the current information about the negative regulation of cytokine JAK-STAT signaling by SOCSs in normal immune physiology but they also contribute to the development of different pathological conditions such as inflammatory diseases, oncology, pulmonology and allergology. Focusing the discussion on a family of SOCS-proteins, suppressors of cytokine signaling, is very important for a better understanding of immune mechanisms of inflammation, and this acquired knowledge will assist the development of novel therapeutic strategies. (Cytokines and Inflammation. 2012. Vol. 11. № 2. P. 14–22.)

Keywords: SOCS, suppressor of cytokine signaling, JAK-STAT, cytokines.

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