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Journal 'Cytokines & inflammation', 2013, No. 1

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Original Articles

Number 1'2013

Study of the interleukin 12 family cytokines (IL-12, IL-23, IL-27, IL-35) production in sperm and blood of men, with oligosymptomatic forms of chronic urogenital infection with special reference to fertility

S.Yu. Tsiporenko

The aim of the study was to determine the concentrations of cytokines of IL-12 family (IL-12, IL-23, IL-27, IL-35) in the semen and blood serum of male patients with oligosymptomatic forms of chronic urogenital infection depending on the fertility rate. It was found that increased levels of IL-12 and IL-27 in serum during inflammation in the urogenital tract were accompanied by a significant decrease in sperm. Violation of the cytokine profile of men with inflammation in the genital organs leads to chronic disease and to complications. Reducing the concentration of IL-12, IL-27, IL-35 and the IL-23 increase in the sperm gives rise to the development of infertility. (Cytokines and Inflammation. 2013. Vol. 12. № 1–2. P. 34–37.)

Keywords: urogenital infection, male fertility, interleukine-12 family cytokines.

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