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Journal 'Cytokines & inflammation', 2014, No. 1

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Number 1'2014

Role of cytokines in pathogenesis of chronic urticaria

N.I. Baranova, S.V. Kozhenkova, L.A. Aschina

The review contains updated information on the role of cytokines in the pathogenesis of chronic urticaria. Close attention was paid to the most complex forms of urticaria: cold urticaria, idiopathic, and autoimmune. It is shown that in neurogenic urticaria substance P involved in the processes of neuro-immune regulation specifically activates NF-κB transcription factor, which controls the production of pro-inflammatory cytokines IL-1, IL-6, IL-12 and TNFα by monocytes and macrophages. The features of the expression of several inflammatory cytokines (IL-6, TNFα, IL-3) in the pathogenesis of cold autoinflammatory syndrome are shown. The authors suggest that, in addition to the Th1/Th2 balance, a special role of Th17 imbalance and regulatory cytokines IL-10 and IL-17 should be considered in the pathogenesis of autoimmune form of urticaria. (Cytokines and Inflammation. 2014. Vol. 13. № 1. P. 11–15.)

Keywords: urticaria neurogenic, idiopathic autoimmune, cytokines.

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