Научно-практический журнал
[About us] Journal 'Cytokines & Inflammation'

197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
Web: cytokines.ru


Year 2017
Number 1 Number 2
Number 3

About journal

Current year


Rules for authors

Contact us


Site map

Our partners:


Русский языкEnglish language
Site map Contact us

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2014, No. 1

Subscribe for 2018 year

Order this issue

Order PDF of this article

Original Articles

Number 1'2014

Pathogenic significance of the disorders in metabolic and cytokine homeostasis of amniotic fluid in the development of amniotic membranes incapacity

L.I. Dyatlova, A.V. Mikhaylov, N.P. Chesnokova, E.V. Ponukalina, T.N. Glukhova

30 pregnant women with premature rupture of membranes were examined at 22–34 weeks gestation. The state of lipid peroxidation, the activity of the antioxidant system and the level of cytokines in the amniotic fluid were examined. Significant increase in intermediates of lipid peroxidation (diene conjugates and malondialdehyde) as well as the activation of superoxiddismutase and ceruloplasmin, and the increase in integrative index of antioxidant status (TAS) were detected in amniotic fluid of patients with amniotic membranes incapacity. At the same time, a cytokine imbalance was evident in amniotic fluid with the increase of pro-inflammatory (IL-1β, IL-6, IL-8, TNFα) and decline of anti-inflammatory cytokines (IL-4, IL-10). Thus, the activation of lipid peroxidation in the utero-placental-fetus complex is one of the triggers of destabilization of biological membranes, intercellular matrix, violations of cytokine status in the amniotic fluid and the development of the insolvency of amniotic membranes. (Cytokines and Inflammation. 2014. Vol. 13. № 1. P. 16–22.)

Keywords: cytokines, pregnancy, premature birth, amniotic fluid.

Contents | Next article | Previous article

© 2007-2018 Cytokines and inflammation