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Journal 'Cytokines & inflammation', 2014, No. 1

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Original Articles

Number 1'2014

Autoantibodies to phospholipids and neutrophil elastase in patients with immune deficiency and bronchial asthma or chronic obstructive pulmonary disease

Yu.R. Agapova, A.V. Gulin, E.V. Malysheva

Serum levels of autoantibodies to phospholipids and neutrophil elastase (with ELISA) and γ-globulin fraction (with electrophoresis on cellulose acetate) were studied in patients with acute exacerbation of chronic obstructive pulmonary disease and bronchial asthma. It was shown that autoantibodies and immunoglobulin deficiency were present only in patients with moderate and severe disease, with prolonged course and frequent exacerbations. It is recommended to identify and correct such shifts. (Cytokines and Inflammation. 2014. Vol. 13. № 1. P. 41–46.)

Keywords: COPD, asthma, exacerbation, antiphospholipid antibodies, antibodies to elastase, gamma globulins.

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