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Journal 'Cytokines & inflammation', 2015, No. 2

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Original Articles

Number 2'2015

T lymphocytes and macrophages in unstable atherosclerotic lesions in humans

P.V. Pigarevsky, V.A. Snegova, S.V. Maltseva, N.G. Davydova

The analysis of immunoinflammatory reactions in human vascular wall showed that numerous cellular infiltrates in superficial and deep parts of intima are characteristic of unstable atherosclerotic lesions. Helper T cells prevailed among CD3 T lymphocytes in an unstable atherosclerotic plaque. We made an assumption that paraaortal lymph nodes can be a possible source of T lymphocytes in a vascular wall. We stated a hypothesis that matrix metalloproteinases which cause thinning and destruction of a fibrous cup of atherosclerotic plaques can be one of the mechanisms leading to formation of unstable lesions in humans. (Cytokines and Inflammation. 2015. Vol. 14. № 2. P. 84–87.)

Keywords: T lymphocytes, macrophages, unstable atherosclerotic plaque, atherogenesis.

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