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Journal 'Cytokines & inflammation', 2015, No. 2

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Original Articles

Number 2'2015

Investigation of Toll-like receptor 4 gene expression in the upper airway mucosa

E.V. Tyrnova, G.M. Aleshina, Y.K. Yanov, V.N. Kokryakov

The evaluation of TLR4 gene expression in the surface epithelium of the upper airway mucosa had been performed. 210 surgical samples of nasal and maxillary sinuses mucosa (inferior turbinate mucosa, the mucosa of the middle nasal passage, polyps), tympanic and mastoid cavity and laryngeal mucosa, adenoids, palatine tonsils were investigated. Estimation of TLR4 and beta-actin gene expression by the levels of the corresponding mRNA synthesis was performed by real-time PCR. The expression of TLR4 gene was detected in the most samples of adenoids and tonsillar epithelium, but it was absent in most samples of the nasal and sinonasal mucosa, the middle ear mucosa and in all samples of the laryngeal mucosa. Diverse expression of TLR4 in different parts of the upper airway mucosa suggests a region-specific functional modulation of the innate immune system. Probably, since upper airway mucosa surfaces are colonized by the physiological and pathogenic microbiota, activation of epithelial TLRs must be tightly controlled to avoid unintended stimulation and mucosal inflammation. (Cytokines and Inflammation. 2015. Vol. 14. № 2. P. 35–41.)

Keywords: upper airway mucosa, Toll-like receptor 4, real-time polymerase chain reaction.

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