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Journal 'Cytokines & inflammation', 2015, No. 3

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Number 3'2015

Tissue-specific isoform expression as a mechanism for cytokine function regulation

A.N. Silkov, S.V. Sennikov

The tissue and cell specificity of alternative splicing and expression of cytokine isoforms are reviewed. Mechanisms of generation of alternative transcripts make a significant contribution to the formation of specialized functions inherent to specific tissues and cell types and are essential part of adaptation mechanisms. It is also considered the contribution of cytokine isoforms to microenvironment formation, migration and determining the functional repertoire of immune system cells. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 5–9.)

Keywords: cytokines, alternative splicing, isoforms, tissue specificity, gene expression.

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