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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

A study of acute and chronic inflammation in brain ischemia on the model of isolated neutrophils

E.Yu. Solov'eva, O.A. Baranova, A.V. Chekanov, O.M. Panasenko, D.T. Chipova, L.B. Tlapshokova, I.V. Miachin, A.N. Karneev, A.I. Fedin

Research is devoted to the study of the development of inflammatory response in patients with acute ischemic stroke (AIS) and chronic cerebral ischemia (CCI) on the model of isolated neutrophils and by assessing the level of myeloperoxidase (MPO) in the blood plasma. Using the methods of neutrophil chemiluminescence and enzyme immunoassay, it was shown that the level of neutrophil activity directly correlates with clinical outcome in in-hospital patients with AIS. Also, a high level of chronic inflammation was demonstrated in patients with CCI. Determination of MPO levels in blood plasma may be an important prognostic factor in patients with stroke. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 60–64.)

Keywords: brain ischemia, inflammation, neutrophils, cytokines, myeloperoxidase.

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