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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

The relationships between humoral anti-endotoxic immunity, metabolic toxicity and oxidative stress in influenza

D.K. Shmoylov, T.N. Odinets, I.Z. Karimov, A.S. Midikari, M.V. Horovenko

The aim was to identify the changes in the levels of IgM and IgG antibodies to bacterial endotoxin, the degree of metabolic toxicity, oxidative stress and acute phase response in patients with influenza A of moderate severity. IgM and IgG antibodies to bacterial LPS (anti-LPS IgM, anti-LPS IgG) and C-reactive protein (CRP) were determined in blood sera by ELISA, and concentrations of medium-molecular-weight molecules (MMM) and the degree of oxidative protein modification (OMP) — by spectrophotometry. We found an increased level of anti-LPS IgM in the initial stage of the disease (3–4 times), but later on anti-LPS IgM decreased and was almost normal in convalescence. With the development of bacterial complications, in the midst of the disease (the 3rd day), the anti-LPS IgM content was twice or more as high as normal level. Indices of metabolic intoxication (MMM, OMP and CRP) showed a similar trend of changes. The character of correlations points indirectly to the pathogenetic relationship of bacterial endotoxemia, endogenous metabolic toxicity and oxidative stress. (Cytokines and Inflammation. 2015. Vol. 14. 3. P. 76–82.)

Keywords: influenza, antiendotoxi immunity, metabolic intoxication.

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