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Journal 'Cytokines & inflammation', 2015, No. 3

Clinical and pathogenetic features of the interaction between IL-1 system and vasoconstrictive factors in patients with essential hypertension

O.A. Radaeva, A.S. Simbirtsev

The aim of this study was to evaluate the levels of serum cytokines (IL-1β, IL-1α and IL-1Ra), vasoconstrictive factors (angiotensin II, endothelin-1) and the degree of blood pressure increase in women and men with essential arterial hypertension (EAH) and to analyze the effects of standard antihypertensive treatment. Serum IL-1β, IL-1α and IL-1Ra levels were measured with an enzyme-linked immunosorbent assayin 300 patients (200 women and 100 men) with II stage ЕAН aged 51,5±2,8 years during 5 year period. Patients with EAH had higher serum levels of IL-1β, IL-1α, angiotensin II, endothelin-1 compared with healthy individuals. Women with EAH had higher angiotensin II and endothelin-1 levels, but lower blood pressure compared with age-matched men. Likewise, the increase in SBP and DBP were correlated with level of IL-1α in women with EAH. In contrast, in the male group, the degree of increase of SBP was significantly associated with levels of angiotensin II, endothelin-1 and IL-1β. Understanding the cytokine mechanisms responsible for gender differences in hypertension will be important for developing gender-specific therapies targeted toward the prevention and treatment of hypertension. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 83–89.)

Keywords: essential hypertension,.

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