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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Blood proinflammatory cytokines in patients with lichen sclerosus of the vulva

D.F. Porsokhonova, Yu.A. Alimukhamedova, A.M. Medjitova, M.L. Rosstalnaya

The article contains the results of clinical, immunological and microbiological studies in patients with lichen sclerosus (kraurosis) of the vulva. After a brief outline of the disease etiopathogenesis, authors prove the need for detailed microbiological studies of the urogenital tract of patients with lichen sclerosus of the vulva and examine the blood contents of the main pro-inflammatory cytokines TNFα, IL-1, IL-2, IL-6, IFNγ. As a result of studies, the presence of one or another urogenital tract infection was observed in all women. HPV occurred in 29 (82,8 %) patients, including types 16, 18 — 13 (37,1 %), HSVII — in 27 (77,1 %), CMV — in 26 (74,3 %), Candida — in 25 (71,4 %), Ureaplasma urealyticum — in 19 (54,3 %), Gardnerella vaginalis — in 16 (45,7 %), Mycoplasma genitalis — in 4 (11,4 %). A significant increase in the concentration of TNFα, IL-1, IL-2 and IL-6 and nonsignificant increase in IFNγ were found . Based on these data, it was suggested that the persistence of viral agents plays an important role in the genesis of vulvar lichen sclerosus, and that proinflammatory cytokines are involved directly or indirectly in the implementation of pruritus. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 99–102.)

Keywords: lichen sclerosus, vulva, proinflammatory cytokines.

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