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Journal 'Cytokines & inflammation', 2015, No. 3

Analysis of gene IL20 associations with psoriasis

E.S. Galimova, E.K. Khusnutdinova

The molecular basis of the pathogenesis of psoriasis, the chronic inflammatory skin disease, remains unclear, but principal clinical features of psoriasis — proliferation and abnormal differentiation of epidermal keratinocytes, the growth and dilation of blood vessels and the leukocyte infiltration of the dermis and epidermis, appear to be driven mainly by various cytokines and chemokines released by the activated T-cell population. The aim of this replication study was to determine whether variant rs1400986 of IL20 gene is associated with susceptibility to psoriasis. A total of 273 patients with psoriasis and 298 matched healthy controls were enrolled to carry out a case-control study. Genotyping was performed using the Real-Time PCR. Our preliminary data suggest that polymorphism rs1400986 located in IL20 gene related to inflammatory and immunity processes showed an association with disease severity and age at onset. The results of this study are expected to lead to the development of personified approach to psoriasis patients. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 103–107.)

Keywords: association, psoriasis, genetics, cytokine genes, IL-20.

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