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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Interleukin profile of children with the injury of the spleen and patients underwent splenectomy in the remote period

Z.F. Kharaeva, A.Ch. Chegembaev

Interleukin profile was determined in children with spleen trauma and in patients who had undergone splenectomy in a remote period. Serum concentrations of IL-1β, IL-2, IL-10 were investigated. Patients with the injured, but saved spleen, as well as patients who had undergone splenectomy, showed an interleukin imbalance, which consists in a significant decrease in the levels of pro-inflammatory cytokine IL-1β. No significant differences depending on the time of injury and splenectomy were found, indicating the absence of compensation for the immune function of the spleen. Thus, in the spleen injury, despite the organ preservation, as well as after splenectomy, is necessary to consider an interleukin imbalance that apparently is one of the frequent causes of bacterial and viral infections, and requires immunotherapy. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 108–111.).

Keywords: splenectomy, spleen trauma, interleukins.

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