Научно-практический журнал
[About us] Journal 'Cytokines & Inflammation'

197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
E-mail:
Web: cytokines.ru


  


Year 2016
Number 1 Number 2
Number 3 Number 4

About journal

Current year
Archive

Columns
Subscription

Rules for authors

Contact us

Search

Site map

Our partners:

https://pornoseksxxx.com/

Русский языкEnglish language
Site map Contact us

Contents | Previous article

Journal 'Cytokines & inflammation', 2015, No. 3

Subscribe for 2018 year

Order this issue

Order PDF of this article

Original Articles

Number 3'2015

Assessment of oxidative status as an efficacy index in periodontal soft tissue inflammatory and degenerative lesions treatment with toothpastes in rats

E.V. Mokrenko, P.D. Shabanov

A rat model of inflammatory and degenerative lesions of the smooth periodontal tissue by means of administration of 2% formaldehyde water solution into the smooth periodont tissues is described. The oxidative state of rats including lipid peroxidation and antioxidant defense system indices was assessed because of their high sensitivity to inflammation process. The lipid peroxidation indices (malonicdialdehyde and dienic conjugates level) were 2–3-fold higher in the blood serum and periodont tissue in 7 days after inflammation beginning. The system of antioxidant defense (recovered glutathione level and activity of superoxide dismutase) was more sensitive in comparison with lipid peroxidation. The recovered glutathione content in the blood serum was decreased from 2,02±0,09 to 0,88±0,21 µM/ml, and superoxide dismutase activity was reduced from 0,78±0,10 to 0,28±0,04 А/mgprotein, that was these indices were decreased 2,5–3 times. The same regularity was observed in the smooth tissues of the periodont. The recovered glutathione level was decreased 2,1 times and superoxide dismutase activity 7 times. Therefore, the curative and prevention action of toothpastes and stomatologic drugs could be assessed with this model of inflammation. In particular, the toothpastes «Lesmin-dent»>«Clamin-dent»>«Zhemchug» (in order of descending activity) attenuated or abolished signs of inflammatory and degenerative damage of the smooth periodont tissue in rats assessed by lipid peroxidation and antioxidant defense system indices. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 112–115.)

Keywords: periodont, inflammation, oxidative stress, toothpastes.

Contents | Previous article


© 2007-2017 Cytokines and inflammation