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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Soluble cell adhesion molecules in children with intestinal inflammatory diseases

V.I. Ashkinazi, M.Y. Lebedev, E.I. Rudneva, N.Y. Shirokova, E.N. Fedulova, O.A. Tutina, T.A. Kuznetsova

Objective: To investigate the levels of soluble cell adhesion molecules (sP-selectin, sPECAM-1) in the blood serum of children with intestinal inflammatory diseases (IID) and to establish how these molecules’ concentration correlates with some inflammatory markers. Materials and methods: 194 patients with Crohn's disease and ulcerative colitis aged 6 to 17 years were assessed. The levels of sP-selectin, sPECAM-1, cytokines, neopterin, mannose-binding lectin and leukocyte elastase were assessed with the enzyme multiplied immunoassay technique (EMIT). Oxygen-dependent metabolism was studied with the chemiluminescent reaction. Results: The sP-selectin and sPECAM-1 levels were found to be significantly higher in children with IID than in those in the control group which may influence the leukocyte effector function. These findings conformed to the quantitative assay of the intestinal mucosal biopsy, where pronounced inflammatory development was found. At the same time, respiratory metabolism of neutrophils was found to increase and the levels of neopterin, mannose-binding lectin, leukocyte elastase and tumour necrosis factor alpha were found to be growing. Conclusion: increase in sP-selectin and sPECAM-1 may be one of the links in the chain of Crohn's disease and ulcerative colitis development, which is confirmed by the revealed correlation with the assessed inflammatory markers. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 24–29.)

Keywords: intestinal inflammatory diseases, soluble cell adhesion molecules, inflammatory markers.

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