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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Correction of cytokine status in ischemic lesions of the heart and brain using TES-therapy

S.A. Zanin, A.Kh. Kade, A.I. Trofimenko, V.V. Onopriev, A.V. Malysheva, M.O. Makarova

A problem of therapy of ischemic stroke (IS) and myocardium infarction (MI), as variants of severe somatic pathology, is one of the most actual in modern medicine. This fact dictates necessity of the development of experimental models of these conditions adequate for their studying. Using rat models of cerebral ischemia and heart attack developed in present study, plasma levels dynamics of pro- and anti-inflammatory cytokines and β-endorphin were investigated in comparison with control group of animals. Experiments were carried out on 100 male rats, divided in a random way into 5 groups: 1 — control group, 2 — IS modelling, 3 — IS modelling and TES therapy, 4 – MI modelling, and 5 — MI modelling and TES therapy. Blood plasma levels of IL-1β, IL-6, IL-10 and β-endorphin were measured with ELISA on the days 1, 3 and 7 after the onset of experiment. Results indicate that the systemic inflammatory response was seen from the 1st day, and was most expressed in the 2nd and 4th groups of rats. In the 3rd and 5th groups, its development was slowed down by applied TES therapy. This points to the need to find a safe and cost-effective methods of treatment of these vascular accidents. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 30–34.)

Keywords: a stroke, a heart attack, cytokines, TES therapy.

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