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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Features of immune response in patients with community-acquired pneumonia with endogenous intoxication of different degrees of severity

B.I. Gel'tser, A.P. Kim, V.N. Kotel'nikov, A.B. Makarov

The state of cellular and humoral immunity, the level of pro- and anti-inflammatory cytokines (IFNγ, TNFα, IL-4 and IL-10) were studied before and after treatment in patients with community-acquired pneumonia (CAP) with different degrees of endogenous intoxication (EI) severity. It was found that with increasing degree of EI, a decrease in T-cell involvement with prevalence of B-cell component of the immune system, and cytokine imbalances manifested in increased secretion of TNF-α and IL-10 and decreased production of IFN-γ and IL-4 were observed. These changes indicate formation of Th2 type immune response. Standard therapy of CAP promotes activation of T-cell immunity with overproduction of immunoglobulin by B cells. Thus, in CAP patients with III degree of EI in the period of convalescence, the level of T helpers/ inducers is reduced, and the levels of IL-10 and TNFα increased as compared to control (p<0,05). These disorders of the immune system essentially supplement EI pathophysiological characteristics and can be used to monitor clinical recovery of patients with CAP. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 35–41.)

Keywords: community-acquired pneumonia, endogenous intoxication.

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