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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

Condition of the complement system during the first episode of the demyelinating diseases, multiple sclerosis and clinically isolated syndrome

N.B. Serebrynaya, S.V. Lobzin, I.I. Kula, A.M. Ischenko

The complement proteins are known to contribute to demyelinating. In multiple sclerosis (MS), the products of the complement activation (C1q, C3d and C5b–9) are accumulated in the damaged areas of brain, which suggests that complement is involved in the myelin sheath degradation, death of oligodendrocytes and neurons. We have observed 22 patients with the onset of a demyelinating disease defined as clinically isolated syndrome (CIS). 9 patients developed a confirmed MS over the observation period. The data we have received show that the concentrations of 4, 5, H factor and C3a in these patients were significantly different from healthy persons. We have also found significant differences in the concentration of non-activated complement factors (3, 4, 5, factor) between CIS and MS patients. The concentration of all non-activated complement factors was significantly lower in cerebrospinal fluid than in blood plasma. It was only the concentration of the C3 anaphylatoxin that was significantly higher in the cerebrospinal fluid than in the peripheral blood. The research confirmed the pathogenetic involvement of the complement system in the development of autoimmune process in MS whereas the concentrations of C3, C3a, C4, C5, H factor may become informative markers to distinguish between CIS and MS patients. (Cytokines and Inflammation. 2015. Vol. 14. 3. P. 42–46.)

Keywords: multiple sclerosis, clinically isolated syndrome, complement.

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