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Journal 'Cytokines & inflammation', 2015, No. 3

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Original Articles

Number 3'2015

The levels of subclinical inflammation markers in patients with ischemic heart disease predisposed to psychological distress

A.N. Sumin, A.V. Osokina, N.V. Fedorova, O.I. Raikh, O.N. Hryachkova, O.L. Barbarash

Aim: To investigate markers of subclinical inflammation in patients with coronary heart disease (CHD) with and without type D personality. Material and Methods. We examined 744 patients with CHD — 597 (80.2 %) men and 147 (19.7 %) women, aged 57.5 (51; 63) years. From them, 507 patients (68.14 %) were tested for the presence or absence of the type D personality. In this group, concentrations of non-specific marker of subclinical inflammation were determined in 131 patients: matrix metalloproteinase (MMP) -2, -3, -9, tissue inhibitors of matrix metalloproteinases (TIMP) -1, -2, soluble CD40 ligand (sCD40L), neopterin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF) α. For further analysis, patients were divided in two groups: group I (n=44) —type D patients and group II (n = 87) – non-type D patietnts. Results. In both groups, patients did not differ in clinical and anamnestic data. Significant differences were found when comparing the two groups by the level of MMP-2, MMP-9, sCD40L, total cholesterol, low density lipoprotein cholesterol and atherogenicity index. Type D patients had higher average concentration of MMP-2 than non-D patients (195 ng/ml vs 169 ng/ml, p=0.037). In non-D type patients, there was an increase in the levels of MMP-9 and sCD40L (p=0.028 and p=0.006). Other investigated biomarkers (MMP-3, TIMP-1, TIMP-2, neopterin, CRP, IL-6, TNF) were not related to personal characteristics of patients. Conclusion. Higher level of MMP-2 in patients with type D personality may indicate the relative predominance of the process of fibrosis in them. Cytokine profile in non-D type patients is more characteristic of acute process. Based on these data it is possible to think about the prevalence of behavioral component in the influence of type D personality upon prognosis in patients CHD. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 53–59.)

Keywords: type D personality, subclinical inflammation, ischemic heart disease.

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