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Journal 'Cytokines & inflammation', 2015, No. 3

The levels of subclinical inflammation markers in patients with ischemic heart disease predisposed to psychological distress

A.N. Sumin, A.V. Osokina, N.V. Fedorova, O.I. Raikh, O.N. Hryachkova, O.L. Barbarash

Aim: To investigate markers of subclinical inflammation in patients with coronary heart disease (CHD) with and without type D personality. Material and Methods. We examined 744 patients with CHD — 597 (80.2 %) men and 147 (19.7 %) women, aged 57.5 (51; 63) years. From them, 507 patients (68.14 %) were tested for the presence or absence of the type D personality. In this group, concentrations of non-specific marker of subclinical inflammation were determined in 131 patients: matrix metalloproteinase (MMP) -2, -3, -9, tissue inhibitors of matrix metalloproteinases (TIMP) -1, -2, soluble CD40 ligand (sCD40L), neopterin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor (TNF) α. For further analysis, patients were divided in two groups: group I (n=44) —type D patients and group II (n = 87) – non-type D patietnts. Results. In both groups, patients did not differ in clinical and anamnestic data. Significant differences were found when comparing the two groups by the level of MMP-2, MMP-9, sCD40L, total cholesterol, low density lipoprotein cholesterol and atherogenicity index. Type D patients had higher average concentration of MMP-2 than non-D patients (195 ng/ml vs 169 ng/ml, p=0.037). In non-D type patients, there was an increase in the levels of MMP-9 and sCD40L (p=0.028 and p=0.006). Other investigated biomarkers (MMP-3, TIMP-1, TIMP-2, neopterin, CRP, IL-6, TNF) were not related to personal characteristics of patients. Conclusion. Higher level of MMP-2 in patients with type D personality may indicate the relative predominance of the process of fibrosis in them. Cytokine profile in non-D type patients is more characteristic of acute process. Based on these data it is possible to think about the prevalence of behavioral component in the influence of type D personality upon prognosis in patients CHD. (Cytokines and Inflammation. 2015. Vol. 14. № 3. P. 53–59.)

Keywords: type D personality, subclinical inflammation, ischemic heart disease.

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