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Journal 'Cytokines & inflammation', 2015, No. 4

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Original Articles

Number 4'2015

The role of cytokine gene polymorphisms in oral lichen planus

G.M. Akmalova, S.V. Chuykin, G.I. Ron, I.R. Gilyazova, N.D. Chernysheva, E.S. Galimova, E.K. Khusnutdinova

To assess the association of cytokine gene polymorphisms (rs2430561 in IFNG gene, rs7747909 in IL-17A gene, rs187238 in IL-18 gene) with the development of oral lichen planus (OLP) and the disease recurrence we performed real-time PCR in OLP patients (n=93) and healthy individuals (n=163) of Russian ethnic origin, living in the Volga-Ural region of Russia. We revealed allele rs2430561*A in the IFNG gene to be associated with OLP (OR = 1.18). Genotype rs2430561*A/A was found to be the genetic marker of the increased risk for severe exudative-hyperemic OLP form (OR= 4.49). The increase of rs2430561*T allele dose decreases the risk of OLP recurrence (OR=0.56). We found rs187238 in IL18 gene to be associated with OLP development and OLP recurrence in the recessive model. The results of the study confirm the contribution of cytokine gene polymorphisms to OLP development. (Cytokines and Inflammation. 2015. Vol. 14. № 4. P. 17–23.)

Keywords: oral.

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