Научно-практический журнал
[About us] Journal 'Cytokines & Inflammation'

197376, Санкт-Петербург, ул. Акад. Павлова, д. 12,
Институт экспериментальной медицины РАМН
Тел.: (812) 543 52 14, +7 921 984 11 30, +7 921 909 55 49
Факс: (812) 543 52 14
E-mail:
Web: cytokines.ru


  


Year 2016
Number 1 Number 2

About journal

Current year
Archive

Columns
Subscription

Rules for authors

Contact us

Search

Site map

Our partners:

https://pornoseksxxx.com/

Русский языкEnglish language
Site map Contact us

Contents | Next article | Previous article

Journal 'Cytokines & inflammation', 2015, No. 4

Order this issue

Order PDF of this article

Original Articles

Number 4'2015

The role of cytokine gene polymorphisms in oral lichen planus

G.M. Akmalova, S.V. Chuykin, G.I. Ron, I.R. Gilyazova, N.D. Chernysheva, E.S. Galimova, E.K. Khusnutdinova

To assess the association of cytokine gene polymorphisms (rs2430561 in IFNG gene, rs7747909 in IL-17A gene, rs187238 in IL-18 gene) with the development of oral lichen planus (OLP) and the disease recurrence we performed real-time PCR in OLP patients (n=93) and healthy individuals (n=163) of Russian ethnic origin, living in the Volga-Ural region of Russia. We revealed allele rs2430561*A in the IFNG gene to be associated with OLP (OR = 1.18). Genotype rs2430561*A/A was found to be the genetic marker of the increased risk for severe exudative-hyperemic OLP form (OR= 4.49). The increase of rs2430561*T allele dose decreases the risk of OLP recurrence (OR=0.56). We found rs187238 in IL18 gene to be associated with OLP development and OLP recurrence in the recessive model. The results of the study confirm the contribution of cytokine gene polymorphisms to OLP development. (Cytokines and Inflammation. 2015. Vol. 14. № 4. P. 17–23.)

Keywords: oral.

Contents | Next article | Previous article


© 2007-2017 Cytokines and inflammation