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Journal 'Cytokines & inflammation', 2016, No. 2

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Number 2'2016

Cytokines in the pathogenesis of multiple sclerosis. Part I. Cytokines of innate immunity

G.F. Zheleznikova, N.V. Skripchenko, L.A. Alekseeva, E.Y. Skripchenko

The review presents the publications of the previous 5-7 years (from Pubmed basically) devoted to the investigation of cytokines in multiple sclerosis clinical picture. There are discussed the results of comparison of systemic and local response of innate immunity cytokines and clinical disease manifestations. The pathogenetic value of pro-inflammatory (TNFα, IL-1β, IL-6, IL-7, IL-15, IL-21, IL-23, IL-33, osteopontin) and anti-inflammatory (TGFβ, IL-10, IL-25, IL-27, IFNα/β) cytokines is considered. (Cytokines and Inflammation. 2016. Vol. 15. № 2. P. 121–132.)

Keywords: review, multiple sclerosis, innate immunity, cytokines.

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