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Journal 'Cytokines & inflammation', 2016, No. 2

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Number 2'2016

Epithelial cells of the female reproductive tract as a component of the innate immune system

V.I. Shcherbakov, T.I. Ryabichenko, G.A. Skosyreva, A.N. Trunov, L.A. Trunova

Data on the possibility of epithelial cells of the female reproductive tract to recognize the infectious origin through the Toll-like receptors are presented. The consequence of this recognition of pathogens is the synthesis and secretion of immunoactive substances aimed at protection from the infectious origin, such as natural antimicrobial polypeptides, defensins, cytokines, chemokines. A wide range of secreted products makes it possible to carry out such reactions as antibacterial, antiparasitic, antifungal and antiviral. More broadly, these substances carry out microbicidal, anti-inflammatory and immunomodulating functions and maintenance of tissue homeostasis. Based on the data presented, it may be suggested that epithelial cells are able to perform many of the functions inherent in immune cells. Their behavior influences the development of inflammation. This allows us to refer them to an important compartment of the innate immune system and extends our understanding of the body's ability to resist the infectious onset, and will also help to create new technologies for the inflammation prevention and treatment. (Cytokines and Inflammation. 2016. Vol. 15. № 2. P. 133–139.).

Keywords: female reproductive tract, epithelial cells, innate immunity.

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