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Journal 'Cytokines & inflammation', 2016, No. 3

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Original Articles

Number 3'2016

Cytokine regulation and immunonociceptive interrelations at different stages of the formation of mental and behavioral disorders caused by the use of psychoactive substances

D.N. Savochkina, E.I. Masterova, T.I. Nevidimova, N.A. Bokhan

Changes in cytokine balance in addictive pathology deserve special attention as cytokines are capable to exert impact on neurotransmitter systems, to change pain sensitivity and to cause a complex of behavioral reactions. The aim was to study the changes in the activity of IL-1β and IL-6 and immunonociceptive interactions at different stages of the formation of mental and behavioural disorders caused by the use of psychoactive substances (PAS).. Examination was conducted in 72 probands, 58 men and 14 women, with mean age of 23.4±6.4 years, divided into groups of (i) persons with mental and behavioral disorders caused by the use of PAS (PAS dependent persons) (n=37), (ii) persons with PAS episodic use (n=7) and (iii) conventionally healthy persons (control group) (n=28). Interrelationships of IL-1β and IL-6 levels, their regulatory factors and parameters of nociception in the examined groups were identified. Possible mutual regulation of activity of two cytokines by means of receptor antagonists and soluble receptors was found in persons dependent on PAS. Possible participation of IL-1β and IL-6 in the nociceptive mechanism of maintenance of pathological craving to PAS was shown. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 290–295.)

Keywords: cytokine regulation, nociception, addiction.

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