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Journal 'Cytokines & inflammation', 2016, No. 3

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Original Articles

Number 3'2016

Proinflammatory cytokines in the diagnosis of complications after allogeneic hematopoietic stem cells transplantation in children

T.M. Doroshenko, S.T. Akalovich, V.A. Bakerova, Т.V. Shman, Iu.E. Mareiko, M.B. Belevtsev, O.V. Aleinikova, N.N. Voitenok

We have studied a diagnostic value of plasma level of tumor necrosis factor (TNF), soluble tumor necrosis factor receptor 1 (sTNFR1) and interleukin 8 (IL-8) in children after hematopoietic stem cell transplantation (n=35) as biomarkers of post-transplantation complications — for acute graft-versus-host disease (GVHD) and infection/sepsis. We have identified that the plasma level of sTNFR1 in patients with acute GVHD increased more than twofold compared to level before conditioning (р=0.001), while in patients without GVHD the level of sTNFR1 was not changed significantly. Determination of sTNFR1 can be used for the clinical management of patients undergoing hematopoietic stem cell transplantation to confirm the diagnosis of acute GVHD as an additional method. Diagnostic efficiency of the method is as follows: sensitivity — 83%, specificity — 94 %.Since we have shown that the infections cause significant increase in plasma level of sTNFR1 — to 11,7±9,0 times (р=0,03), the infectious complications is a limitation on the method application. Measurement of IL-8 can be used as an additional criterion for the diagnosis of infection/sepsis, but as a marker of the GVHD it does not have sufficient diagnostic value. (Cytokines and Inflammation. 2016. Vol. 15. № 3–4. P. 279–284.)

Keywords: hematopoietic stem cell transplantation, acute graft-versus-host disease, infection, soluble tumor necrosis factor receptor-1, interleukin-8.

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