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Year 2017
Number 3

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Journal 'Cytokines & inflammation', 2017, No. 3

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Brief communications

Number 3'2017

The serum levels of IL-12 p40, p70, and IFNγ in women with herpetic infection

T.A. Nevezhkina, S.V. Knysh, L.S. Matyushkina, A.A. Potapenko, E.V. Baibarina

The herpes simplex virus (HSV) is an urgent problem for all segments of the population around the world. The effects of IL-12 p40 and p70, and IFNγ in the immunopathogenesis of HSV, now require further study. Objective: The comparative characteristics of IL-12 p40, p70, and IFNγ in serum of women with HSV infection. Materials and methods: Blood serum of 39 female patients from 25 to 44 years. Patients were divided into 3 groups: I group – with infection associated with HSV type 1 (20 people), group II with HSV type 2 (12 people) and group III – control group of practically healthy women (7 people). Results: a statistically significant decrease in IL-12 p40 and p70 in both main groups was revealed, however, IFNγ was significantly increased in group I, and decreased in group II, in comparison with the control group. Conclusion: An inverse correlation was found between the average strength of IFNγ and IL-12 p70 (r=-0.51). The biological properties of IL-12 are to protect the body from infection, so deficiency of IL-12 leads to a violation of activation of the Th1 response and an adaptive immunity defect in HSV-2 infection. (Cytokines and Inflammaton. 2017. Vol. 16. № 3. P. 52–54.)

Keywords: Herpes simplex virus, immunopathogenesis, IL-12, IFNγ, blood serum, women.

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