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Year 2017
Number 3

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Journal 'Cytokines & inflammation', 2017, No. 3

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Brief communications

Number 3'2017

Role of IL-12p40 and IL-12p70 in pathogenesis of herpetic infection

S.V. Knysh, T.A. Nevezkina, N.A. Zukovich, V.A. Malkov, E.V. Baibarina

The immune mechanism of shingles pathogenesis stays unclear. The role of IL-12 also is ambiguous. Purpose: comparative analysis of IL-12p40 and IL-12p70 serum levels in 25 patients with herpes zoster; control group consisted of 25 healthy donors. Results: A decrease in IL-12p40 and IL-12p70 levels in blood serum of herpes zoster patients was found (p<0,05). Conclusion: IL-12 deficiency can lead to NK cells dysfunction. (Cytokines and Inflammaton. 2017. Vol. 16. № 3. P. 42–44.)

Keywords: herpes, shingles, IL-12, cytokines.

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